为了解决上述挑战,Varanasi团队通过改造纳米级结构来实现蛋白质浓度的局部提升,同时提供一个模板,让蛋白质能够正确排列并形成晶体。相关研究成果以“Enhancing Protein Crystal Nucleation Using In Situ Templating on Bioconjugate-Functionalized Nanoparticles and Machine Learning”为题发表于ACS Applied Materials & Interfaces。
[1]Caroline McCue, Henri-Louis Girard, Kripa K. Varanasi. Enhancing Protein Crystal Nucleation Using In Situ Templating on Bioconjugate-Functionalized Nanoparticles and Machine Learning. ACS Applied Materials & Interfaces, 2023; DOI: 10.1021/acsami.2c17208